Development of a fast-acting nanosuspension nasal drop using a novel co-processed polymer for migraine relief

Nikhil  Shrisunder; Prashant Kumar  Dhakad; Ritu  Gilhotra

doi:10.69857/joapr.v13i3.940

Authors

Nikhil Shrisunder School of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India
Prashant Kumar Dhakad School of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India
Ritu Gilhotra School of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India

DOI:

https://doi.org/10.69857/joapr.v13i3.940

Keywords:

Nanosuspension, Nasal Drop, Prochlorperazine Maleate, Migraine treatment, Bioavailability

Abstract

Background: Effective central nervous system (CNS) drug delivery remains challenging due to the blood-brain barrier. Nasal drug delivery offers a non-invasive alternative, ensuring rapid drug absorption and onset of action. Prochlorperazine Maleate, a drug for migraines, suffers from poor solubility, limiting its therapeutic potential. Methodology: A nanosuspension-based nasal drop was developed and optimized using high-pressure homogenization. A novel co-processed polymer enhances solubility and stability. Key formulation parameters, including particle size, zeta potential, and polymer concentration, were optimized using a central composite design. The optimized nanosuspension was characterized for its physicochemical properties, drug release, and stability. Results and Discussion: The optimized formulation (Batch F9) exhibited a particle size of 78.8 nm and a high drug release rate (93.87% in 8 hours). Stability studies confirmed no significant changes in drug content, pH, or osmolality over a three-month period. The nasal drop provided consistent dosing, with each actuation delivering a precise amount of drug content. In vitro drug release studies demonstrated a sustained release pattern, enabling prolonged migraine relief. Conclusion: The developed nanosuspension nasal drop presents a promising solution for CNS drug delivery, ensuring rapid and sustained therapeutic outcomes. This nanosuspension nasal drop achieved a 5.6-fold enhancement in solubility and demonstrated rapid onset within 10 minutes post-administration. Although promising, the study is limited to in vitro characterization; future research should explore in vivo efficacy and long-term safety.

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