A brief overview of sustained released drug delivery system


  • Priyanka Prajapat Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan
  • Dilip Agrawal Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan
  • Gaurav Bhaduka Mahatma Gandhi College of Pharmaceutical Sciences, Jaipur, Rajasthan https://orcid.org/0000-0002-3217-4350




Sustain release dosage form, drug delivery system, controlled release system, half-life


The most popular and patient-friendly method of drug administration is often thought to be the oral route of administration. Compared to conventional release formulations, advancements in formulation technology, including modified release dosage forms or sustained release oral dosage forms, have been extensively accepted. A sustained release dosage form provides a prolonged release of the drug over an extended period, thereby giving better patient compliance and enhanced bioavailability. Sustain release systems are considered a wiser approach for drugs with short half-lives requiring repeated dosing. Sustained release drug delivery has a range of advantages over conventional dosage forms, including increased patient compliance due to less frequent drug administration, significantly reduced steady state drug level fluctuations, maximum drug utilization, the increased safety margin of potent drugs, lower healthcare costs due to improved therapy, and shorter treatment times. The present review focuses on design, fabrication, and various factors that influence the performance of sustained-release dosage forms.


Download data is not yet available.


Bhowmik D, Kumar KPS, Dutta A, Paswan S. Trends in scope and opportunities of control release oral drug delivery systems. Critical Review in Pharmaceutical Sciences, 1(1), 20-33 (2012)

Vamsy KA, Srinath KR, Chowdary PC. Formulation development and evaluation of Divalproex sodium extended release tablet. International Journal of Research pharmaceutical and Biomedical Science, 2(1), 809-832(2011)

Patel H, Panchal DR, Patel U, Brahmbhatt T. Matrix Type Drug Delivery System: A Review. Journal of Pharmaceutical Science and Bioscientific Research, 3(1), 143-51 (2011)

Kumar KPS, Bhowmik D, Srivastava S. Sustained Release Drug Delivery System Potential. The Pharma Inovation, 2(1), 48-60(2017).

Lee TW, and Robinson JR, In Remington: The science and practice of pharmacy, Gennaro, 23th edition, Baltimore, Lippincott Williams and Wilkins, 903-929 (2008).

Ansel HC, Allen LV, and Popovich NG, Pharmaceutical dosage forms and drug delivery system, 9thedition, Lippincott William & Wilkins, 257-271 (2005).

Chien YW, Rate controlled drug delivery systems, 2nd edition, Marcel Dekker, New York, revised and expanded 2(1) 2005.

Chauhan MJ, Patel SA. A Concise Review on Sustained Drug Delivery System and Its Opportunities. American Journal of PharmTech Research, 2(2), 227-238(2012).

Chugh I, Seth N, Rana AC. Oral sustained release drug delivery system: An overview. International Research Journal of Pharmacy, 3(5), 57-62 (2012)

Bhalla N, Deep A, Goswami M. An Overview on various approaches to oral controlled drug delivery system via Gastroretentive Drug Delivery System. International Research Journal of Pharmacy, 3(4), 128-133 (2016)

Dusane RA, Gaikwad PD, Bankar VH, Pawar SP. A Review on: Sustained release technology. International Journal of Research in Ayurveda and Pharmacy 2(6), 1701-1708 (2015).

Jain NK, Drug delivery system, Methods in molecular biology, Humana Press 3(1) 218(2012)

Wani MS, Controlled Release System-A Review, www.pharmainfo.net/review 6(1) (2008)

Bechgaard H, Nielson GH. Controlled release multiple units and single unit dosage. Drug Dev. & Ind. Pharm. 4(1), 53-67(2002)

Aulton ME, Modified release peroral dosage forms, Pharmaceutics- The science of Dosage form Design, 2nd edition, Churchill Livingstone, New York, 2(1) 290 (2004)

Marroum. PJ Bioavailability/Bioequivalence for Oral controlled release products, Controlled release drug delivery systems: Scientific and Regulatory Issues. Fifth International Symposium on Drug Development, 3 (1), 15–17 (1997).

Banker GS, and Rhodes CT, Sustained and Controlled drug delivery system, Modern Pharmaceutics, 4th edition, Marcel Dekker, New York, 4(1), 212-229 (2002).

Shargel L, Pong SW, and Yu AB, Modified-release drug products, Applied Biopharmaceutics & Pharmacokinetics, 5th Edition, August 312-322 (2004).

Gupta D, Bhatt DC. Studies on enteric coated sustained timed-release tablets of Metronidazole. Journal of Chemical and Pharmaceutical Research, 2(2), 226-232 (2010)

Pogula M, Nazeer S. Extended Release Formulation. International Journal of Pharmacy and Technology. 2(4), 625- 684 (2010).

Modi SA, Gaikwad PD, Bankar VH, Pawar SP. Sustained Release Drug Delivery System: A Review, International Journal of Pharmaceutical Research and Development, 2(1), 147-160 (2011).

Brahmannkar DM, and Jaiswal SB, Controlled released medication, Biopharmaceutics and Pharmacokinetic, 335-346 (1985).

Kumar V, Prajapati SK, Soni GC, Singh M. Sustained release matrix type drug delivery system: A Review. World Journal of Pharmacy and Pharmaceutical Sciences, 1(3), 934-960 (2012)

Wise DL, Venkatraman S, Davar N, and Chester A, An Overview of Controlled Release Systems, Handbook of Pharmaceutical Controlled Release Technology, Marcel Dekker, New York, 431-464 (2000)

Kumar S, Gupta V, Malodia K. Oral Extended Release Drug Delivery System: A Promising Approach. Asian Journal of Pharmacy and Technology, 2(2), 38-43(2012)

Ho WH, and Lee VHL, Influence of drug properties on design, Controlled Drug Delivery Fundamentals and Applications, 2ndedition, Marcel Dekker, New York, 2(1), 16-25 (1987)

Ho WH, and Lee HLV, Design and fabrication of oral controlled release drug delivery system, Controlled Drug Delivery Fundamentals and Applications, 2ndedition, Marcel Dekker, New York, 2(1), 373-420 (1987)



How to Cite

Prajapat, P. ., Agrawal, D. ., & Bhaduka , G. . (2022). A brief overview of sustained released drug delivery system. Journal of Applied Pharmaceutical Research, 10(3), 05-11. https://doi.org/10.18231/j.joapr.2022.