Traditional and medicinal use of Barbaloin: potential for the management of various diseases


  • Navdeep Singh Laureate Institute of Pharmacy, V.P.O. Kathog, Teh. Jawalamukhi, Distt. Kangra-176031, Himachal Pradesh
  • Kamya Goyal Department of Pharmaceutical Chemistry and Analysis, Laureate Institute of Pharmacy, V.P.O. Kathog, Teh. Jawalamukhi, Distt. Kangra-176031, Himachal
  • Shivi Sondhi Laureate Institute of Pharmacy, V.P.O. Kathog, Teh. Jawalamukhi, Distt. Kangra-176031, Himachal Pradesh
  • Shammy Jindal Department of Pharmaceutics, Laureate Institute of Pharmacy, V.P.O. Kathog, Teh. Jawalamukhi, Distt. Kangra-176031, Himachal Pradesh



Barbaloin, Extraction, Properties, Potential on skin disorders


Barbaloin is the phytoconstituent which is obtained from the plant known as aloe vera.  As we all know aloe vera is the main curative medicinal plants, has been traditionally used as alternative treatment against the many skin diseases. Barbaloin extracted from the aloe vera plant which is physically light yellow colored powder. Extraction of barbaloin from the plant Aloe barbadensis Miller had been accomplished by the Soxhelt extraction, Batch extraction experiment and Ultrasound assisted extraction method (UAE). Barbaloin showed various kinds of therapeutic and medicinal properties like anti-diabetic, antioxidants, anti-cancer, anti-inflammatory and and anti-microbial. It also has good effect on cardiovascular system, test perception, enzyme or metabolism and bioavailability. Our Skin plays an important role in the development of skin diseases because there are many types of skin disorders are developed and the variety of disorders may result to dermatitis or they affect the social wellbeing of a person. Due to their good pharmacological activities, Barbaloin have great potential to treat the different type of skin disorders like Eczema, Psoriasis, Burns and wound, Acne, Dandruff, Frostbite, Rashes, Cold sores, Razor burn and Sunburn. To access the effective use of barbaloin there are various attempts have been experimented on the subject of their Pharmacological activities to check their effect on skin disease and the steps regarding the Isolation of barbaloin also has been made. We can examine their effects on chronic skin diseases. In this review article we discuss about the potential of barbaloin on skin disorders, medicinal importance or Pharmacological activities and their methods of extraction.


Download data is not yet available.


Gutterman Y, Chauser-Volfson E. The distribution of the phenolic metabolites barbaloin, aloeresin and aloenin as a peripheral defense strategy in the succulent leaf parts of Aloe arborescens. Biochem. Syst. Ecol., 28, 825–38 (2000).

Chang XL, Wang C, Feng Y, Liu Z. Effects of heat treatments on the stabilities of polysaccharides substances and barbaloin in gel juice from Aloe vera Miller. J. Food Eng., 75, 245–51 (2006).

Brown PN, Yu R, Kuan CH, Finley J, Mudge EM, Dentali S. Determination of aloin A and aloin B in Aloe vera raw materials and finished products by high-performance liquid chromatography: Single-laboratory validation. J. AOAC Int., 97, 1323–8 (2014).

Pandey DK, Malik T, Banik RM. Quantitative Estimation of Barbaloin in Aloe vera and its Commercial Formulations by Using HPTLC. Int. J. Med. Aromat. Plants, 2, 420–7 (2012).

Groom QJ, Reynolds T. Barbaloin in Aloe species. Planta Med., 53, 345–8 (1987).

Gupta R, Thakur B, Singh P, Singh HB, Sharma VD, Katoch VM, Chauhan SVS. Anti-tuberculosis activity of selected medicinal plants against multi-drug resistant Mycobacterium tuberculosis isolates. Indian J. Med. Res., 131, 809–13 (2010).

Wamer WG, Vath P, Falvey DE. In vitro studies on the photobiological properties of aloe emodin and aloin A. Free Radic. Biol. Med., 34, 233–42 (2003).

Avila H, Rivero J, Herrera F, Fraile G. Cytotoxicity of a low molecular weight fraction from Aloe vera (Aloe barbadensis Miller) gel. Toxicon, 35, 1423–30 (1997).

Auterhoff H, Graf E, Eurisch G, Alexa M. Trennung des Aloins in Diastereomere und deren Charakterisierung. Arch. Pharm. (Weinheim)., 313, 113–20 (1980).

Shivatare RS, Nagore DH, Nipanikar SU. ‘HPTLC’ an important tool in standardization of herbal medical product : A review. J. Sci. Innov. Res., 2, 1086–96 (2013).

Elamthuruthy AT, Shah CR, Khan TA, Tatke PA, Gabhe SY. Standardization of marketed Kumariasava - An Ayurvedic Aloe vera product. J. Pharm. Biomed. Anal., 37, 937–41 (2005).

Jawade NR, Chavan AR. Ultrasonic -assisted extraction of aloin from aloe vera gel. Procedia Eng., 51, 487–93 (2013).

Jawade NR, Chattopadhyay S. Optimization of Batch Extraction Parameters for Aloin from Aloe Vera Gel. 8–10 (2011).

Kou D, Mitra S. Extraction of Semivolatile Organic Compounds from Solid Matrices. (2003).

Knorr D. Impact of non-thermal processing on plant metabolites. J. Food Eng., 56, 131–4 (2003).

Schinor EC, Salvador MJ, Turatti ICC, Zucchi OLAD, Dias DA. Comparison of classical and ultrasound-assisted extractions of steroids and triterpenoids from three Chresta spp. Ultrason. Sonochem., 11, 415–21 (2004).

Vinatoru M. An overview of the ultrasonically assisted extraction of bioactive principles from herbs. Ultrason. Sonochem., 8, 303–13 (2001).

L W, X B. The Extraction Technology of Flavonoids from Buckwheat. Agrotechnology, 06, 2–4 (2017).

Devine J. Applications of ultrasound. Tech. Text. Int., 295–326 (1993).

Qadariyah L, Mahfud M, Sulistiawati E, Swastika P. Natural Dye Extraction from Teak Leves (Tectona Grandis) Using Ultrasound Assisted Extraction Method for Dyeing on Cotton Fabric. MATEC Web Conf., 156, 4–7 (2018).

Alves DS, Pérez-Fons L, Estepa A, Micol V. Membrane-related effects underlying the biological activity of the anthraquinones emodin and barbaloin. Biochem. Pharmacol., 68, 549–61 (2004).

Huichun Z, Ruiqin F, Xiaoguang D, Linpei J. Study of the Eu(III)-barbaloin-CTAB system by fluorescence and determination of barbaloin. Anal. Lett., 31, 819–28 (1998).

Grimaudo S. Effects of highly purified anthraquinoid compounds from Aloe vera on sensitive and multidrug resistant leukemia cells. Oncol. Rep., 4, 341–3 (1997).

Pérez YY, Jiménez-Ferrer E, Zamilpa A, Hernández-Valencia M, Alarcón-Aguilar FJ, Tortoriello J, Román-Ramos R. Effect of a polyphenol-rich extract from aloe vera gel on experimentally induced insulin resistance in mice. Am. J. Chin. Med., 35, 1037–46 (2007).

Beppu H, Shimpo K, Chihara T, Tamai I, Nomoto-Yamaji S, Ozaki S, Ito S, Kuzuya H. Inhibitory effects of aloe carboxypeptidase fraction on streptozotocin-induced enhancement of vascular permeability in the pancreatic islets. Phytomedicine, 13, 49–60 (2006).

Tian B, Hua Y. Concentration-dependence of prooxidant and antioxidant effects of aloin and aloe-emodin on DNA. Food Chem., 91, 413–8 (2005).

Kambizi L, Afolayan AJ. Extracts from Aloe ferox and Withania somnifera inhibit Candida albicans and Neisseria gonorrhoea. African J. Biotechnol., 7, 012–5 (2008).

van Zyl RL, Viljoen AM, Jäger AK. In vitro activity of Aloe extracts against Plasmodium falciparum. South African J. Bot., 68, 106–10 (2002).

Ferox LOE. Anti-viral effects of aqueous extracts of Somnifera Withania. S. Afr. J. Sci., (2007).

Saleem R, Faizi S, Siddiqui BS, Ahmed M, Hussain SA, Qazi A, Dar A, Ahmad SI, Qazi MH, Akhtar S, Hasnain SN. Hypotensive effect of chemical constituents from Aloe barbadensis. Planta Med., 67, 757–60 (2001).

Pronin AN, Xu H, Tang H, Zhang L, Li Q, Li X. Specific Alleles of Bitter Receptor Genes Influence Human Sensitivity to the Bitterness of Aloin and Saccharin. Curr. Biol., 17, 1403–8 (2007).

Lee MC, Liao J Der, Huang WL, Jiang FY, Jheng YZ, Jin YY, Tseng YS. Aloin-induced cell growth arrest, cell apoptosis, and autophagy in human non-small cell lung cancer cells. Biomarkers Genomic Med., 6, 144–9 (2014).

Barrantes E, Guinea M. Inhibition of collagenase and metalloproteinases by aloins and aloe gel. Life Sci., 72, 843–50 (2003).

Park MY, Kwon HJ, Sung MK. Evaluation of aloin and aloe-emodin as anti-inflammatory agents in aloe by using murine macrophages. Biosci. Biotechnol. Biochem., 73, 828–32 (2009).

Chung JH, Cheong JC, Lee JY, Roh HK, Cha YN. Acceleration of the alcohol oxidation rate in rats with aloin, a quinone derivative of Aloe. Biochem. Pharmacol., 52, 1461–8 (1996).

Shim SMI, Kwon H. assessing absorbability of bioactive components in aloe using In Vitro digestion model with human intestinal cell. J. Food Biochem., 34, 425–38 (2010).

Dawid-Pać R. Medicinal plants used in treatment of inflammatory skin diseases. Postep. Dermatologii i Alergol., 30, 170–7 (2013).

Klein AD, Penneys NS. Aloe vera. J. Am. Acad. Dermatol., 18, 714–20 (1988).

Laxmi RJ, Karthikeyan R, Babu PS, Babu RVVN. Formulation and evaluation of antipsoriatic gel using natural excipients. J. Acute Dis., 2, 115–21 (2013).

Moriyama M, Moriyama H, Uda J, Kubo H, Nakajima Y, Goto A, Akaki J, Yoshida I, Matsuoka N, Hayakawa T. Beneficial effects of the genus Aloe on wound healing, cell proliferation, and differentiation of epidermal keratinocytes. PLoS One, 11, 1–15 (2016).

Akhoondinasab MR, Akhoondinasab M, Saberi M. Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. World J. Plast. Surg., 3, 29–34 (2014).

Mazzarello V, Donadu MG, Ferrari M, Piga G, Usai D, Zanetti S, Sotgiu MA. Treatment of acne with a combination of propolis, tea tree oil, and aloe vera compared to erythromycin cream: Two double-blind investigations. Clin. Pharmacol. Adv. Appl., 10, 175–81 (2018).

Lorentzen AK, Davis C, Penninga L. Interventions for frostbite injuries. Cochrane Database Syst. Rev., 2018, (2018).

Kumar KPS, Bhowmik D, Chiranjib, Biswajit. Aloe vera: a potential herb and its medicinal importance. Jounal Chem. Pharm. Res., 2, 21–9 (2010).

Rajeswari R,, M. Umadevi CSR, , S. Selvavenkadesh, K. P. Sampath Kumar DB. Aloe vera: The Miracle Plant Its Medicinal and Traditional Uses in India. J. Pharmacogn. Phytochem., 1, 118–24 (2012).

Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: A systematic review. J. Tradit. Complement. Med., 5, 21–6 (2015).

Qadir M. Medicinal and cosmetological importance of Aloe vera. Int. J. Nat. Ther., 2, 21–6 (2009).



How to Cite

Singh, N., Goyal, K., Sondhi, S. ., & Jindal, S. (2020). Traditional and medicinal use of Barbaloin: potential for the management of various diseases. Journal of Applied Pharmaceutical Research, 8(3), 21-30.