JAPR Journal of Applied Pharmaceutical Research 2348-0335 Publishing India Group japr-1-1-006 Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug GoswamiD. S. 1, * UppalN. 1 1Department of Pharmaceutics, S.D. College of Pharmacy, Barnala, Punjab-148101 *For Correspondence: dhrubasv@gmail.com 10–12 2013 1 1 31 35 Abstract

The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs.

 Keywords Captopril transdermal therapeutic system ethyl cellulose (EC) polyvinyl References ArunachalamA KarthikeyanM KumarVD PrathapM SethuramanS. Transdermal drug delivery system: A review. Curr Pharm Res. 2010; 1 (1): 70–81. SelvamPR KumarSA KumarST . Transdermal drug delivery systems for antihypertensive drugs - A review. Int J Pharm Biomed Res. 2010; 1 (1): 1–8. TripathiKD , Antihypertensive agents. In: Essentials of medical pharmacology. Edn:6. New Delhi: Jaypee brothers; 2008. p. 445–450. SharanG DeyKB DasS KumarVS . Effect of various permeation enhancers on propranolol hydrochloride formulated patches. Int J Pharmacy Pharm Sci. 2010; 2 (2): 21–31. GuptaJRD IrchhiayaR GarudN TripathiP DubeyP. Formulation and evaluation of transdermal patches of glibenclamide. Int J Pharm Sci Drug Res. 2009; 1 (1): 46–50. VermaPP IyerSS . Transdermal delivery of propanolol using mixed grade of eudragit: Design and in vitro and in vivo evaluation. Drug Dev Ind Pharm. 2000; 26: 471–476. DeviVK SaisivamS MariaGR . Design and evaluation of matrix diffusion controlled transdermal patches of verapamil hydrochloride. Drug Dev Ind Pharm. 2003; 29: 495–503. RaoV MamathaT MukkantiK Ramesh . Transdermal drug delivery system for atomoxetine hydrochloride in vitro and ex vivo evaluation. Curr Trends Biotech Pharmacy. 2009; 3 (2): 188–96. DeyBK NathLK MohantiB BhowmikBB . Development and evaluation of propranolol hydrochloride transdermal patches by using hydrophilic and hydrophobic polymer. Ind J Pharm Edu Res. 2007; 41 (4): 388–393. SonjoyM RatanGN . Formulation and evaluation of carvedilol transdermal patches. Int Res J Pharmacy. 2011; 2 (1): 237–248.